A Biochemical study on the effect of some treatments on bone resorption and formation in osteoporotic rats: Thesis Abstract

Thesis Abstract Osteoporosis thins bones, weakening them and making more susceptible to fractures. It may be related withdrawal of sex hormones by ageing. Objective: the present study was conducted evaluate bone protective effects Raloxifene, Risedronate, their combination on osteoporotic male female rats. Methods: induced orchidectomy (ORX) 35 Wistar rats ovariectomy (OVX) 50 Four weeks post surgery, each ORX OVX were randomized into 4 groups: control, Raloxifene (RAL), Risedronate (RIS) Raloxifene+Risedronate (RAL+RIS). RAL dose 3 mg/kg given orally times/week. RIS 5µg/kg s.c. injection, twice weekly. After 6 treatment, alkaline (ALP) acid phosphatase (ACP) activities, mineral density (BMD), histochemical localization ALP, gene expression osteoprotegerin (OPG) morphogenetic protein-2(BMP-2) examined. Results: The showed a significant increase in plasma ALP ACP activities activity as compared with sham, attenuated treatment RIS. BMD femur didn't change after gonadectomy. In OVX-RAL ORX-RIS, improved untreated Gene OPG BMP-2 down regulated versus but up-regulated treatments. rats, down-regulated treatment. Conclusions: Both reduced turnover maintained